Lu Zhiwu

Prof. Lu Zhiwu

Education Background：

2021.07–2024.07 College of Chemistry and Molecular Sciences, Wuhan University; (Sauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education)

Postdoctoral Fellow in Chemistry; Supervisor: Prof. Wen-Bo Liu

2018.09−2021.06 College of Chemistry and Molecular Sciences, Wuhan University; (Sauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education)

Ph.D. in Chemistry; Supervisor: Prof. Wen-Bo Liu

2015.06−2018.09 Department of Chemistry, Southern University of Science and Technology; (Shenzhen Grubbs Institute)

Research assistant; Supervisor: Prof. Jun (Joelle) WANG

2012.09−2015.06 Yunnan Minzu University; (YMU-HKBU Joint Laboratory of Traditional Natural Medicine; Key Laboratory of Chemistry in Ethnic Medicinal Resources)

M.S. in Organic Chemistry; Supervisor: Prof. Baomin Fan

2008.09−2012.06 Shuda College, Hunan Normal University; (Key Laboratory of Chemical Biology Traditional Chinese Medicine Research, Ministry of Education)

B.S. in Pharmaceutical Engineering

Academic Career：

2024.07-present Associate Professor, Department of Chemistry, Guangxi Minzu University (Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission)

Publications:

1. Zhiwu Lu, Ke Zhai, Weimin Liu, Yu-Qing Zheng, and Wen-Bo Liu.* Stereodivergent Construction of 1,3-Nonadjacent Stereocenters Enabled by Nickel-Catalyzed Cyclization and 1,4-Reduction Reaction. J. Am. Chem. Soc. 2026, in preparation.

2. Zhiwu Lu, Weimin Liu, Ke Zhai, Xu-Dong Hu,* and Wen-Bo Liu.* Enantioselective Construction of Spirocyclohexenones via Ni-Catalyzed Double Arylative Cyclization of Alkyne-Tethered Malononitriles.doi.org/10.1021/acs.joc.5c02474.

3. Jian Long, Zhiwu Lu, Xiao-Lin Li, Peng Xue, and Wen-Bo Liu.* Ni-Catalyzed Enantioselective Difunctionalization of Alkynes to Azepine Derivatives Bearing a Quaternary Center and an Unprotected Imine. Chin. J. Chem. 2024, 42, 873–878.

4. Wei-Min Liu, Zhiwu Lu (co-first author), Qiang Wei, and Wen-Bo Liu.* Enantioselective Nickel-Catalyzed Reductive anti-Arylative Annulation of Alkyne-Tethered Malononitriles to Construct Quaternary Stereocenters. Org. Lett. 2023, 25, 1811–1816.

5. Zhiwu Lu (co-first author), Xu-Dong Hu (co-first author), Hui Zhang, Xiao-Wen Zhang, Jinhui Cai, Muhammad Usman, Hengjiang Cong, and Wen-Bo Liu.* Enantioselective Assembly of Cycloenones with a Nitrile-Containing All-Carbon Quaternary Center from Malononitriles Enabled by Ni Catalysis. J. Am. Chem. Soc. 2020, 142, 7328−7333.

6. Zhiwu Lu, Haoyang Zhang, Zhiping Yang, Ning Ding, Ling Meng, and Jun Wang.* Asymmetric Hydrophosphination of Heterobicyclic Alkenes: Facile Access to Phosphine Ligands for Asymmetric Catalysis. ACS Catal. 2019, 9, 1457−1463.

7. Jinhui Cai, Zhen-Kai Wang, Muhammad Usman, Zhi-Wu Lu, Xu-Dong Hu, and Wen-Bo Liu.* Enantioselective Synthesis of β‑Quaternary Carbon-Containing Chromanes and 3,4-Dihydropyrans via Cu-Catalyzed Intramolecular C−O Bond Formation. Org. Lett. 2019, 21, 8852−8856.

8. Dayou Zhong, Di Wu, Yan Zhang, Zhiwu Lu, Muhammad Usman, Wei Liu, Xiuqiang Lu,and Wen-Bo Liu.* Synthesis of Sultams and Cyclic N‑Sulfonyl Ketimines via IronCatalyzed Intramolecular Aliphatic C−H Amidation. Org. Lett. 2019, 21, 5808−5812.

9. Donglu Xiong, Wenxi Zhou, Zhiwu Lu, Suping Zeng and Jun Wang.* A highly enantioselective access to chiral chromanones and thiochromanones via copper-catalyzed asymmetric conjugated reduction of chromones and thiochromones. Chem. Commun., 2017, 53, 6844−6847.

10. Sifeng Li, Zhiwu Lu, Ling Meng and Jun Wang.* Iridium-Catalyzed Asymmetric Addition of Thiophenols to Oxabenzonorbornadienes. Org. Lett. 2016, 18, 5276−5279.

11. Zhiwu Lu, Jun Wang,* Baiqiu Han, Sifeng Li, Yongyun Zhou, and Baomin Fan.* Palladium-Catalyzed Asymmetric Ring Opening Reaction of Azabenzonorbornadienes with Aromatic Amines. Adv. Synth. Catal. 2015, 357, 3121–3125.

12. Yongyun Zhou, Zhiwu Lu, Baiqiu Han, Chaoyuan Zeng, Zhenhua Zhang and Baomin Fan.* Iridium-Catalyzed Highly Enantioselective Ring Opening Reaction of Oxabenzonorbornadienes with Amines. Tetrahedron: Asymmetry. 2015, 26, 1354–1359.

13. Sifeng Li, Jianbin Xu, Baomin Fan,* Zhiwu Lu, Chaoyuan Zeng, Zhaoxiang Bian, Yongyun Zhou, and Jun Wang.* Palladium/Zinc Co-Catalyzedsyn-Stereoselectively Asymmetric Ring-Opening Reaction of Oxabenzonorbornadienes with Phenols. Chem. Eur. J. 2015, 21, 9003–9007.

14. Baomin Fan,* Sifeng Li, Hualei Chen, Zhiwu Lu, Shanshan Liu, Qingjing Yang, Lu Yu, Jianbin Xu, Yongyun Zhou, and Jun Wang.* Palladium/Copper Complexes Co-Catalyzed Highly Enantioselective Ring Opening Reaction of Azabenzonorbornadienes with Terminal Alkynes. Adv. Synth. Catal. 2013, 355, 2827-2832.

Patents:

1. The synthesis of chiral cycloenones bearing a nitrile-containing all-carbon quaternary center. Wen-Bo Liu, Zhiwu Lu, Xu-Dong Hu. Chinese Patent: 202010250039.4.

2. The synthesis of chiral chromanones and thiochromanones. Jun Wang, Donglu Xiong, Wenxi Zhou, Zhiwu Lu. Chinese Patent: ZL201710379364.9.

Projects Led/Participated:

(1) NiH-catalyzed Desymmetricalization of Malononitrile via Cyclized Functionalization of Alkynes (General Program of the China Postdoctoral Science Foundation (2022M712458)), 8w, 2022.06-2024.06, Principal Investigator.

(2) Iron-Catalyzed Regioselective C–H Amination via Nitrene Insertion: Ligand-Controlled Activity and Asymmetric Induction (General Program of the National Natural Science Foundation of China), 65w, 2020.01-2023.12, Co-Investigator.

(3) Asymmetric Catalytic Ring-Opening Reactions of Aza/Oxa-Benzonorbornadienes with Terminal Alkynes (General Program of the National Natural Science Foundation of China), 50w, 2014.01-2017.12, Co-Investigator.

Awards and Honours：

(1) National Scholarship for Doctoral Students (2020);

(2) Outstanding Graduate Student, Wuhan University (2019-2020);

(3) Outstanding Graduate, Wuhan University (Class of 2021);

(4) Second Prize Outstanding Academic Scholarship, Wuhan University (2020);

(5) Excellent Award, Adamas Academic Paper Award (7th Edition, 2020);

(6) Encouragement Award, Adamas Academic Paper Award (7th Edition, 2020);

(7) Outstanding Mid-Term Assessment Award for Master's Students, Yunnan Minzu University (2014).

Conference Presentations:

The 3rd Guangxi Organic Chemistry Forum & International Frontier Symposium on Drug Discovery and Evaluation (Oral Presentations)