Jia-Yu Liao

Dr. Liao Jia-Yu

Educational Background

B.S., Zhejiang University

Ph.D., National University of Singapore

Postdoctoral, National University of Singapore

Employment

2026.01-present Research Assistant Professor, Department of Chemistry, Hong Kong Baptist University

2019.06-2025.12 Research Professor, College of Pharmaceutical Sciences, Zhejiang University

2018.05-2019.05 Senior Scientist, Chemical Development Unit, Novartis

Selected Publications

1. Y. Zhu#, J. Fang#, S. A. H. Ahmed, T. Zhang, S. Zeng, J.-Y. Liao*, Z. Ma*, L. Qian*. A modular artificial intelligence framework to facilitate fluorophore design. Nat. Commun. 2025, 16, 3598.

2. J.-Y. Liao*. Catalytic asymmetric reactions of isocyanides for constructing non-central chirality. Beilstein J. Org. Chem. 2025, 21, 1648-1660 (invited perspective).

3. Y. Huang, J.-Y. Liao*. Catalytic asymmetric desymmetrization of diesters: advances and perspectives. Tetrahedron Chem 2025, 14, 100134 (invited mini-review).

4. W.-T. Wang#, S. Zhang#, W. Lin#, Z.-H. Luo, D. Hu, F. Huang, R. Bai*, Y. Lan, L. Qian*, J.-Y. Liao*. Catalytic stereodivergent and simultaneous construction of axial and point chirality. Org. Chem. Front. 2024, 11, 3308-3319 (selected as back cover).

5. L.-F. Tao, F. Huang, X. Zhao, L. Qian*, J.-Y. Liao*. Atroposelective synthesis of eight-membered lactam-bridged N-arylindoles via stepwise cut-and-sew strategy. Cell Rep. Phys. Sci. 2023, 4, 101697.

6. F. Huang, L.-F. Tao, J. Liu, L. Qian*, J.-Y. Liao*. Diastereo- and enantioselective synthesis of biaryl aldehydes bearing both axial and central chirality. Chem. Commun. 2023, 59, 4487-4490.

7. Z.-H. Luo, W.-T. Wang, T.-Y. Tang, S. Zhang, F. Huang, D. Hu, L.-F. Tao, L. Qian, J.-Y. Liao*. Torsional Strain-Independent Catalytic Enantioselective Synthesis of Biaryl Atropisomers. Angew. Chem. Int. Ed. 2022, 61, e202211303 (selected as Hot Paper).

8. L.-F. Tao#, S. Zhang#, F. Huang, W.-T. Wang, Z.-H. Luo, L. Qian*, J.-Y. Liao*. Diastereo- and Enantioselective Silver-Catalyzed [3+3] Cycloaddition and Kinetic Resolution of Azomethine Imines with Activated Isocyanides. Angew. Chem. Int. Ed. 2022, 61, e202202679.

9. S. Zhang, Z.-H. Luo, W.-T. Wang, L. Qian*, J.-Y. Liao*. Simultaneous Construction of C-N Axial and Central Chirality via Silver-Catalyzed Desymmetrizative [3+2] Cycloaddition of Prochiral N-Aryl Maleimides with Activated Isocyanides. Org. Lett. 2022, 24, 4645-4649.

10. W.-T. Wang#, S. Zhang#, L.-F. Tao, Z.-Q. Pan, L. Qian*, J.-Y. Liao*. Cooperative catalysis-enabled C-N bond cleavage of biaryl lactams with activated isocyanides. Chem. Commun. 2022, 58, 6292-6295 (selected as Chemical Communications HOT Articles 2022).

11. J. Shao#, Y. Liu#, J. Yan#, Z.-Y. Yan, Y. Wu, Z. Ru, J.-Y. Liao*, X. Miao*, L. Qian*. Prediction of Maximum Absorption Wavelength Using Deep Neural Networks. J. Chem. Inf. Model. 2022, 62, 1368-1375.

12. L. Qian#, L.-F. Tao#, W.-T. Wang, E. Jameel, Z.-H. Luo, T. Zhang, Y. Zhao, J.-Y. Liao*. Catalytic Atroposelective Dynamic Kinetic Resolution of Biaryl Lactones with Activated Isocyanides. Org. Lett. 2021, 23, 5086-5091.